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Germany , Wednesday 27 May 2020

News Germany Mannheim: Metastasis-associated fibroblasts promote angiogenesis in metastasized pancreatic cancer via the CXCL8 and the CCL2 axes

Published on: Tuesday 24 March 2020
Metastasis-associated fibroblasts promote angiogenesis in metastasized pancreatic cancer via the CXCL8 and the CCL2 axes
News source: https://www.nature.com/articles/s41598-020-62416-x

The characteristic desmoplastic stroma of pancreatic ductal adenocarcinoma (PDAC) is a key contributor to its lethality. This stromal microenvironment is populated by cancer-associated fibroblasts (CAFs) that interact with cancer cells to drive progression and chemo-resistance. Research has focused on CAFs in the primary tumour but not in metastases, calling into question the role of analogous metastasis-associated fibroblasts (MAFs). We infer a role of MAFs in murine hepatic metastases following untargeted treatment with the anti-angiogenic drug sunitinib in vivo. Treated metastases were smaller and had fewer stromal cells, but were able to maintain angiogenesis and metastasis formation in the liver. Furthermore, sunitinib was ineffective at reducing MAFs alongside other stromal cells. We speculate that cancer cells interact with MAFs to maintain angiogenesis and tumour progression. Thus, we tested interactions between metastatic pancreatic cancer cells and fibroblasts using in vitro co-culture systems. Co-cultures enhanced fibroblast proliferation and induced angiogenesis. We identify carcinoma-educated fibroblasts as the source of angiogenesis via secretions of CXCL8 (aka IL-8) and CCL2 (aka MCP-1). Overall, we demonstrate that metastasis-associated fibroblasts have potential as a therapeutic target and highlight the CXCL8 and CCL2 axes for further investigation.

News Germany Mannheim: Germany sees number of coronavirus deaths rise by a third

Published on: Wednesday 25 March 2020
Germany sees number of coronavirus deaths rise by a third
News source: https://www.dailymail.co.uk/news/article-8154783/Germany-sees-number-coronavirus-deaths-rise-third.html

The Robert Koch health institute today reported 49 new deaths in Germany, taking the total from 149 to 198.(the increasing death toll is shown on a graph).

News Germany Mannheim: Cinema Libre Studio Takes U.S. Rights to ’My Little One’ (EXCLUSIVE)

Published on: Wednesday 11 March 2020
Cinema Libre Studio Takes U.S. Rights to ’My Little One’ (EXCLUSIVE)
News source: https://variety.com/2020/film/news/cinema-libre-studio-takes-us-rights-my-little-one-1203530299/

Los Angeles-based production-distribution house Cinema Libre Studio has acquired U.S. rights to Frédéric Choffat and Julie Gilbert’s “My Little One,” in the wake of its U.S. premiere at the Miami ...

News Germany Mannheim: Park Systems Opens Park Nanoscience Center Equipped with Cleanroom and Line of Academic and Industrial Tools

Published on: Wednesday 11 March 2020
Park Systems Opens Park Nanoscience Center Equipped with Cleanroom and Line of Academic and Industrial Tools
News source: https://finance.yahoo.com/news/park-systems-opens-park-nanoscience-070000490.html

With the beginning of 2020, Park Systems, a leading innovator of atomic force microscopy (AFM) technology, increases the business investment in Europe by inaugurating a new scientific facility for academic and industrial research in Mannheim, Germany.

News Germany Mannheim: Tim Stutzle leading next generation of Germany’s elite hockey talent

Published on: Friday 03 January 2020
Tim Stutzle leading next generation of Germany’s elite hockey talent
News source: https://www.theglobeandmail.com/sports/hockey/article-tim-stutzle-leading-next-generation-of-germanys-elite-hockey-talent/

“He’s fast, he’s tough, he has some creativity. I really like his game.” But the six-foot, 187-pound Stutzle, who plays on a line in Mannheim with former NHLer Ben Smith, is just one of Germany’s ...

News Germany Mannheim: Jennewein Biotechnologie GmbH enforces its patents in the field of human milk oligosaccharides again

Published on: Thursday 09 January 2020
Jennewein Biotechnologie GmbH enforces its patents in the field of human milk oligosaccharides again
News source: http://www.ansa.it/pressrelease/economia/2020/01/10/jennewein-biotechnologie-gmbh-enforces-its-patents-in-the-field-of-human-milk-oligosaccharides-again_529f8ae5-fa79-47a5-aa4e-94db8841e5b1.html

Jennewein Biotechnologie GmbH filed a patent infringement suit with the regional court in Mannheim on January 09, 2020 against Nestlé Nutrition GmbH and its holding company Nestlé Deutschland AG. Nestlé offers its infant formula Beba Supreme which contains two human milk oligosaccharides – unique saccharides naturally occurring in human breast milk only – for sale in Germany. Pursuant to the findi (ANSA)

News Germany Mannheim: Jennewein Biotechnologie GmbH enforces its patents in human milk oligosaccharides against Nestlé in Germany

Published on: Friday 10 January 2020
Jennewein Biotechnologie GmbH enforces its patents in human milk oligosaccharides against Nestlé in Germany
News source: https://www.europapress.es/comunicados/internacional-00907/noticia-comunicado-jennewein-biotechnologie-gmbh-enforces-its-patents-in-human-milk-oligosaccharides-against-nestle-in-germany-20200110162514.html

Jennewein Biotechnologie GmbH filed a patent infringement suit with the regional court in Mannheim on January 09, 2020 against Nestlé Nutrition GmbH ... unique saccharides naturally occurring in human ...

News Germany Mannheim: Carry Yourself With the Confidence of a Male Scientist

Published on: Monday 16 December 2019
Carry Yourself With the Confidence of a Male Scientist
News source: https://www.theatlantic.com/health/archive/2019/12/male-scientists-are-their-own-hype-men/603715/

For a new study, published Monday in the journal BMJ, researchers from Harvard, Yale, and the University of Mannheim in Germany analyzed the gender of the authors of more than 6 million scientific ...

News Germany Mannheim: Animal rights campaigners in Germany launch 'human rights' case on behalf of castrated pigs

Published on: Sunday 15 December 2019
Animal rights campaigners in Germany launch 'human rights' case on behalf of castrated pigs
News source: https://www.dailymail.co.uk/news/article-7795113/Animal-rights-campaigners-Germany-launch-human-rights-case-behalf-castrated-pigs.html

Activists argue that in Germany 'everyone' can file a constitutional complaint if they believe their basic rights have been violated even a pig. But Jens Buelte, a law professor at Mannheim university ...

News Germany Mannheim: At 85 years old, this Connecticut runner has seen war, relocated to another country, beat cancer and is now set for his 50th Manchester Road Race

Published on: Wednesday 27 November 2019
At 85 years old, this Connecticut runner has seen war, relocated to another country, beat cancer and is now set for his 50th Manchester Road Race
News source: https://www.courant.com/sports/hc-sp-manchester-road-race-willi-50-1127-20191128-gqr7exmxwjel7brt3vvz6hg6qy-story.html

Willi Frederich, 85, of Ellington will compete in his 50th Manchester Road Race Thursday. Frederich, who was five years old when World War II started, survived the bombing of Mannheim, his hometown, and after the war, came to America to start a new life. He started running the Manchester Road Race in 1968 and has only missed the race twice.

News Germany Mannheim: “Rona, Azim’s Mother” wins award at Mannheim-Heidelberg film festival

Published on: Wednesday 27 November 2019
“Rona, Azim’s Mother” wins award at Mannheim-Heidelberg film festival
News source: http://www.tehrantimes.com/news/442414/Rona-Azim-s-Mother-wins-award-at-Mannheim-Heidelberg-film

TEHRAN – “Rona, Azim’s Mother”, a co-production between Afghanistan and Iran by Tehran-based Afghan brothers Jamshid and Navid Mahmudi, won the Ecumenical Film Prize at the 68th International Film Festival Mannheim-Heidelberg on Sunday. 

News Germany Mannheim: Get in the Christmas spirit in one of Germany’s oldest cities

Published on: Thursday 05 December 2019
Get in the Christmas spirit in one of Germany’s oldest cities
News source: https://www.stripes.com/get-in-the-christmas-spirit-in-one-of-germany-s-oldest-cities-1.609975

DIRECTIONS: Worms is northwest of Mannheim and less than an hour’s drive from Kaiserslautern ... in Worms to pick up free brochures about the city and find out about guided tours. Address: Neumarkt 14 ...

News Germany Mannheim: Daimler Selects CATL As Global Battery Cell Supplier For Trucks

Published on: Thursday 19 September 2019
Daimler Selects CATL As Global Battery Cell Supplier For Trucks
News source: https://insideevs.com/news/371498/daimler-catl-global-battery-cell-trucks/

Battery pack assembly will be carried out by Daimler Trucks & Buses as well -- at its Mercedes-Benz Mannheim plant in Germany and its Detroit (Michigan) plant in the US. Dr. Frank Reintjes ...

News Germany Mannheim: Amazon hiring own drivers in Germany in a bid to expand delivery business

Published on: Tuesday 17 September 2019
Amazon hiring own drivers in Germany in a bid to expand delivery business
News source: https://www.theglobeandmail.com/business/international-business/us-business/article-amazon-hiring-own-drivers-in-germany-in-a-bid-to-expand-delivery/

“If we have last-mile in our own hands we can offer more services like same-day delivery,” Bernd Gschaider, Germany director for Amazon Logistics, told Reuters at a distribution centre outside the ...

News Germany Mannheim: China’s Qingdao strengthens its blooming cultural and economic friendship with Germany

Published on: Tuesday 11 June 2019
China’s Qingdao strengthens its blooming cultural and economic friendship with Germany
News source: https://www.euronews.com/2019/06/12/china-s-qingdao-strengthens-its-blooming-cultural-and-economic-friendship-with-germany

"China's open door will not be closed, but will only be opened wider and wider," said China’s President Xi Jinping. Central to China’s opening up to the world is Qingdao - the city whose name means “Green Island” is the main node in the New Asia Europe continental bridge and economic corridor.

News Germany Mannheim: Two-way defenseman Moritz Seider ‘shocked’ Red Wings took him at No. 6

Published on: Friday 21 June 2019
Two-way defenseman Moritz Seider ‘shocked’ Red Wings took him at No. 6
News source: https://www.mlive.com/redwings/2019/06/two-way-defenseman-moritz-seider-shocked-red-wings-took-him-at-no-6.html

The Detroit Red Wings selected Seider, a 6-foot-3, 208-pound right-shooting defenseman from Germany, with the sixth selection at ... appearing in 29 games for Mannheim (two goals, four assists). “I ...

News Germany Mannheim: Detroit Red Wings' 2019 NHL draft class: Here's our scouting report

Published on: Saturday 22 June 2019
Detroit Red Wings' 2019 NHL draft class: Here's our scouting report
News source: https://www.freep.com/story/sports/nhl/red-wings/2019/06/22/detroit-red-wings-2019-nhl-draft-class/1535173001/

Vitals: 6-foot-4, 207 pounds. 2018-19 stats: Two goals, four assists in 29 games with Adler Mannheim in Deutsch Eishockey Liga, Germany’s highest league, and five assists in 14 playoff games. [ Steve ...

News Germany Mannheim: Rwanda: Rebel Leader Dies in Germany Awaiting Retrial

Published on: Friday 19 April 2019
News source: https://allafrica.com/stories/201904200036.html

prosecutors argued that Murwanashyaka had directed the militia from his home in Mannheim, in southwest Germany, via phone, text message and email. His lawyers had argued he was only a political ...